The highly conserved histones in different species seem to represent a very ancient and
universal innate host defense system against microorganisms in the biological world …

The COVID‐19 pandemic has been the most significant health crisis in recent global history.
Early studies from Wuhan highlighted COVID‐19‐associated coagulopathy and a significant …

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) had spread from
China and, within 2 months, became a global pandemic. The infection from this disease can …

A state-of-the-art lecture titled “novel mechanisms of thrombo-inflammation during infection”
was presented at the ISTH Congress in 2022. Platelet, neutrophil, and endothelial cell …

Both high mobility group box-1 (HMGB1) and histones are major damage-associated
molecular patterns (DAPMs) that mediate lethal systemic inflammation, activation of the …

The cell-based model of coagulation remains the basis of our current understanding of
clinical hemostasis and thrombosis. Its advancement on the coagulation cascade model has …

Objective Histone proteins are physiologically involved in DNA packaging and gene
regulation but are extracellularly released by neutrophil/monocyte extracellular traps and …

Dysregulation of neutrophil extracellular trap (NET) formation has been shown to mediate
disease pathology in multiple viral infections, including SARS-CoV-2. At the beginning of …

The SARS-CoV-2 infection is characterized by both systemic and organ hyper-
thromboinflammation, with a clinical course ranging from mild up-to critical systemic …

The infectious respiratory condition COVID-19 manifests a clinical course ranging from
mild/moderate up-to critical systemic dysfunction and death linked to thromboinflammation …