Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Label-free microfluidic cell sorting and detection for rapid blood analysis
N Lu, HM Tay, C Petchakup, L He, L Gong, KK Maw… - Lab on a Chip, 2023 - pubs.rsc.org
Blood tests are considered as standard clinical procedures to screen for markers of diseases
and health conditions. However, the complex cellular background (> 99.9% RBCs) and …
and health conditions. However, the complex cellular background (> 99.9% RBCs) and …
A comparison of microfluidic methods for high-throughput cell deformability measurements
The mechanical phenotype of a cell is an inherent biophysical marker of its state and
function, with many applications in basic and applied biological research. Microfluidics …
function, with many applications in basic and applied biological research. Microfluidics …
Microfluidic‐based approaches in targeted cell/particle separation based on physical properties: fundamentals and applications
Cell separation is a key step in many biomedical research areas including biotechnology,
cancer research, regenerative medicine, and drug discovery. While conventional cell sorting …
cancer research, regenerative medicine, and drug discovery. While conventional cell sorting …
Effect of nuclear stiffness on cell mechanics and migration of human breast cancer cells
T Fischer, A Hayn, CT Mierke - Frontiers in cell and developmental …, 2020 - frontiersin.org
The migration and invasion of cancer cells through 3D confined extracellular matrices is
coupled to cell mechanics and the mechanics of the extracellular matrix. Cell mechanics is …
coupled to cell mechanics and the mechanics of the extracellular matrix. Cell mechanics is …
Microfluidic impedance‐deformability cytometry for label‐free single neutrophil mechanophenotyping
The intrinsic biophysical states of neutrophils are associated with immune dysfunctions in
diseases. While advanced image‐based biophysical flow cytometers can probe cell …
diseases. While advanced image‐based biophysical flow cytometers can probe cell …
Cells under stress: an inertial-shear microfluidic determination of cell behavior
The deformability of a cell is the direct result of a complex interplay between the different
constituent elements at the subcellular level, coupling a wide range of mechanical …
constituent elements at the subcellular level, coupling a wide range of mechanical …
Microfluidic deformability cytometry: A review
Y Chen, K Guo, L Jiang, S Zhu, Z Ni, N Xiang - Talanta, 2023 - Elsevier
Cell deformability plays an important role in cellular processes and functions, including cell
growth and differentiation, as well as cell transfer and cell cycle. Measuring deformability at …
growth and differentiation, as well as cell transfer and cell cycle. Measuring deformability at …
Toward deep biophysical cytometry: prospects and challenges
The biophysical properties of cells reflect their identities, underpin their homeostatic state in
health, and define the pathogenesis of disease. Recent leapfrogging advances in …
health, and define the pathogenesis of disease. Recent leapfrogging advances in …
Quantitative phase imaging flow cytometry for ultra‐large‐scale single‐cell biophysical phenotyping
Cellular biophysical properties are the effective label‐free phenotypes indicative of
differences in cell types, states, and functions. However, current biophysical phenotyping …
differences in cell types, states, and functions. However, current biophysical phenotyping …