Mitochondrial impairment: A common motif in neuropsychiatric presentation? The link to the tryptophan–kynurenine metabolic system

M Tanaka, Á Szabó, E Spekker, H Polyák, F Tóth… - Cells, 2022 - mdpi.com
Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

From CGRP to PACAP, VIP, and beyond: unraveling the next chapters in migraine treatment

M Tanaka, Á Szabó, T Körtési, D Szok, J Tajti, L Vécsei - Cells, 2023 - mdpi.com
Migraine is a neurovascular disorder that can be debilitating for individuals and society.
Current research focuses on finding effective analgesics and management strategies for …

Emerging translational research in neurological and psychiatric diseases: From in vitro to in vivo models

M Tanaka, Á Szabó, L Vécsei… - International journal of …, 2023 - mdpi.com
Revealing the underlying pathomechanisms of neurological and psychiatric disorders,
searching for new biomarkers, and developing novel therapeutics all require translational …

Editorial of special issue 'dissecting neurological and neuropsychiatric diseases: Neurodegeneration and neuroprotection'

M Tanaka, L Vécsei - International journal of molecular sciences, 2022 - mdpi.com
This Special Issue has focused on dissecting the neuroprotective and neurodegenerative
components of neurological and neuropsychiatric diseases, highlighting the latest advance …

Integrating armchair, bench, and bedside research for behavioral neurology and neuropsychiatry

M Tanaka, Á Szabó, L Vécsei - Biomedicines, 2022 - mdpi.com
Medical sciences have been steadily paving an exploratory path toward understanding the
mechanisms of mental suffering, such as depression, anxiety, cognitive impairment, and …

Neural correlates and molecular mechanisms of memory and learning

S Battaglia, A Avenanti, L Vécsei, M Tanaka - International journal of …, 2024 - mdpi.com
Memory and learning are essential cognitive processes that enable us to obtain, retain, and
recall information. These factors are crucial for survival, adaptation, and creativity. However …

The Impact of C-3 Side Chain Modifications on Kynurenic Acid: A Behavioral Analysis of Its Analogs in the Motor Domain

D Martos, B Lőrinczi, I Szatmári, L Vécsei… - International journal of …, 2024 - mdpi.com
The central nervous system (CNS) is the final frontier in drug delivery because of the blood–
brain barrier (BBB), which poses significant barriers to the access of most drugs to their …

How well do rodent models of Parkinson's disease recapitulate early non-motor phenotypes? A systematic review

TD Zhang, SC Kolbe, LC Beauchamp, EK Woodbridge… - Biomedicines, 2022 - mdpi.com
The prodromal phase of Parkinson's disease (PD) is characterised by many non-motor
symptoms, and these have recently been posited to be predictive of later diagnosis. Genetic …

Brain–Bone Crosstalk in a Murine Polytrauma Model Promotes Bone Remodeling but Impairs Neuromotor Recovery and Anxiety-Related Behavior

K Ritter, M Baalmann, C Dolderer, U Ritz, MKE Schäfer - Biomedicines, 2024 - mdpi.com
Traumatic brain injury (TBI) and long bone fractures are a common injury pattern in
polytrauma patients and modulate each other's healing process. As only a limited number of …

Use of Ordered Beta Regression Unveils Cognitive Flexibility Index and Longitudinal Cognitive Training Signatures in Normal and Alzheimer's Disease Pathological …

D Alveal-Mellado, L Giménez-Llort - Brain sciences, 2024 - mdpi.com
Generalized linear mixed models (GLMMs) are a cornerstone data analysis strategy in
behavioral research because of their robustness in handling non-normally distributed …