From Data to Cure: A Comprehensive Exploration of Multi-omics Data Analysis for Targeted Therapies

A Mukherjee, S Abraham, A Singh, S Balaji… - Molecular …, 2024 - Springer
In the dynamic landscape of targeted therapeutics, drug discovery has pivoted towards
understanding underlying disease mechanisms, placing a strong emphasis on molecular …

Drug repositioning in non-small cell lung cancer (NSCLC) using gene co-expression and drug–gene interaction networks analysis

H MotieGhader, P Tabrizi-Nezhadi… - Scientific Reports, 2022 - nature.com
Lung cancer is the most common cancer in men and women. This cancer is divided into two
main types, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) …

Application of Machine Learning in Predicting Hepatic Metastasis or Primary Site in Gastroenteropancreatic Neuroendocrine Tumors

MK Padwal, S Basu, B Basu - Current Oncology, 2023 - mdpi.com
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) account for 80% of
gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). GEP-NETs are well …

Identification of common and distinct pathways in inflammatory bowel disease and colorectal cancer: a hypothesis based on weighted gene co-expression network …

A Derakhshani, D Javadrashid, N Hemmat… - Frontiers in …, 2022 - frontiersin.org
Patients with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's
disease, are at higher risk to develop colorectal cancer (CRC). However, the underlying …

Robust Identification of Differential Gene Expression Patterns from Multiple Transcriptomics Datasets for Early Diagnosis, Prognosis, and Therapies for Breast Cancer

KF Tuly, MB Hossen, MA Islam, MK Kibria, MS Alam… - Medicina, 2023 - mdpi.com
Background and Objectives: Breast cancer (BC) is one of the major causes of cancer-related
death in women globally. Proper identification of BC-causing hub genes (HubGs) for …

Exploration of subtype-specific perturbations in breast cancer

G Arora, P Chatterjee, S Chatterjee - Journal of Proteins and Proteomics, 2024 - Springer
Breast cancer remains a leading cause of mortality among women, characterized by its
complex and diverse nature, comprising various molecular subtypes, each demonstrating …

Brain structure and allelic associations in Alzheimer's disease

SW Moon, L Zhao, W Matloff, S Hobel… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Alzheimer's disease (AD), the most prevalent form of dementia, affects 6.5
million Americans and over 50 million people globally. Clinical, genetic, and phenotypic …

Pre-diagnostic circulating RNAs networks identify testicular germ cell tumour susceptibility genes

J Burton, TB Rounge, TB Haugen, MW Wojewodzic - medRxiv, 2022 - medrxiv.org
Testicular germ cell tumour (TGCT) is a malignancy with known inherited risk factors,
affecting young men. We have previously identified several hundred circulating RNAs that …

[PDF][PDF] An integrated breast cancer microarray analysis approach

IO LIXANDRU-PETRE, C BUIU - UPB Sci. Bull., Series C - scientificbulletin.upb.ro
As knowledge of the biological and biophysical basis of cellular function has increased,
opportunities to understand the cellular and molecular functioning of organic matter have …

[PDF][PDF] Gene coexpression networks provide deeper insights into sucrose accumulation in sugarcane cultivars.

MM CARRASCO - repositorio.unicamp.br
Sugarcane (Saccharum spp.) is the most important crop for sugar and first-generation
ethanol production. Modern sugarcane cultivars are highly polyploid and heterozygous …