IL-6 in inflammation, autoimmunity and cancer
T Hirano - International immunology, 2021 - academic.oup.com
IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …
Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs …
T Menter, JD Haslbauer, R Nienhold, S Savic… - …, 2020 - Wiley Online Library
Aims Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2), has rapidly evolved into a sweeping pandemic. Its major …
coronavirus 2 (SARS‐CoV‐2), has rapidly evolved into a sweeping pandemic. Its major …
Effect of tocilizumab vs standard care on clinical worsening in patients hospitalized with COVID-19 pneumonia: a randomized clinical trial
C Salvarani, G Dolci, M Massari, DF Merlo… - JAMA internal …, 2021 - jamanetwork.com
Importance The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of
people worldwide. Tocilizumab has shown promising results in retrospective studies in …
people worldwide. Tocilizumab has shown promising results in retrospective studies in …
COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons
The outbreak of the novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)
responsible for coronavirus disease 2019 (COVID-19) has developed into an …
responsible for coronavirus disease 2019 (COVID-19) has developed into an …
[HTML][HTML] Potential therapeutic options for COVID-19: an update on current evidence
Abstract SARS-CoV-2, a novel coronavirus, is the agent responsible for the COVID-19
pandemic and is a major public health concern nowadays. The rapid and global spread of …
pandemic and is a major public health concern nowadays. The rapid and global spread of …
[HTML][HTML] COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status
BACKGROUND Reprogramming of host metabolism supports viral pathogenesis by fueling
viral proliferation, by providing, for example, free amino acids and fatty acids as building …
viral proliferation, by providing, for example, free amino acids and fatty acids as building …
Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities
LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …
Efficacy and safety of tocilizumab in severe COVID-19 patients: a single-centre retrospective cohort study
Background Tocilizumab (TCZ), a humanized monoclonal antibody targeting the interleukin-
6 (IL-6) receptor, has been proposed for the treatment of COVID-19 patients; however …
6 (IL-6) receptor, has been proposed for the treatment of COVID-19 patients; however …
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines
A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …