Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting
genes and regulatory elements can free themselves from chromosomes and relocate to …

Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high
expression of oncogenes through gene amplification and altered gene regulation. Gene …

Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …

Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are
released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids …

Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of
oncogenic gene expression, evolution of drug resistance and poor patient outcomes …

Blocking cancer genomic instability may prevent tumor diversification and escape from
therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and mice bearing …

Human cancer cell lines have long served as tools for cancer research and drug discovery,
but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we …

Extracellular vesicles (EVs), as natural carriers of bioactive cargo, have a unique
micro/nanostructure, bioactive composition, and characteristic morphology, as well as …

Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to
cause more than 50 diseases,. However, repeat expansions are often not explored beyond …

Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced
and metastatic cancers,,–, but whether they are mechanistically linked is unknown. Here we …