The recent FDA-approval for amyloid lowering therapies reflects an unwavering commitment
from the Alzheimer's disease (AD) research community to identify treatments for this leading …

Sublethal cell damage can trigger senescence, a complex adaptive program characterized
by growth arrest, resistance to apoptosis and a senescence-associated secretory phenotype …

Fibrosing interstitial lung diseases (ILDs) are characterized by the gradual and irreversible
accumulation of scar tissue in the lung parenchyma. The role of the immune response in the …

Senescent cells have a profound impact on the surrounding microenvironment through the
secretion of numerous bioactive molecules and inflammatory factors. The induction of …

The initial excitement generated more than two decades ago by the discovery of drugs
targeting fatty acid synthase (FASN)‐catalyzed de novo lipogenesis for cancer therapy was …

For the past 70 years, the dopamine hypothesis has been the key working model in
schizophrenia. This has contributed to the development of numerous inhibitors of …

Blood-derived products, such as citrate platelet-rich plasma (CPRP) and hyperacute serum
(HAS), are recognized for their rich growth factor content. When human dermal fibroblast …

Objective Measures that capture aging-related decline can identify patients at risk for cardiac
surgery-associated adverse events to guide perioperative care and improve patient …

Background Biological aging begins decades before the onset of age-related clinical
conditions and is mediated by both cellular senescence and declining adaptive immune …

For the past 70 years, dopamine hypothesis has been the key working model in
schizophrenia. This has contributed to the development of numerous inhibitors of …