Oral antiviral treatments for COVID-19: opportunities and challenges

L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …

Unveiling the “template-dependent” inhibition on the viral transcription of SARS-CoV-2

X Luo, X Wang, Y Yao, X Gao… - The Journal of Physical …, 2022 - ACS Publications
Remdesivir is one nucleotide analogue prodrug capable to terminate RNA synthesis in
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) by two distinct mechanisms …

The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b

YZ Lee, HY Hsu, CW Yang, YL Lin, SY Chang… - Pharmaceutics, 2022 - mdpi.com
Ciclesonide is an inhaled corticosteroid used to treat asthma and has been repurposed as a
treatment for mildly ill COVID-19 patients, but its precise mechanism of action is unclear …

[PDF][PDF] Home-based medication management for non-severe SARS-COV-2 infection

P Jonckheer, V Jespers, E Costa… - 2022 - kce.fgov.be
In Belgium, multiple guidances are in use by clinicians concerning the management of
patients with COVID-19 but specific recommendations for the treatment of non-severe …

Bisacodyl Limits Chikungunya Virus Replication In Vitro and Is Broadly Antiviral

NJ LoMascolo, YE Cruz-Pulido… - Antimicrobial agents and …, 2022 - Am Soc Microbiol
Identifying novel antivirals requires significant time and resource investment, and the
continuous threat of viruses to human health necessitates commitment to antiviral …

The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b

L Yue-Zhi, H Hsing-Yu, Y Cheng-Wei, L Yi-Ling… - …, 2022 - search.proquest.com
Ciclesonide is an inhaled corticosteroid used to treat asthma and has been repurposed as a
treatment for mildly ill COVID-19 patients, but its precise mechanism of action is unclear …

Effective Reduction of SARS-CoV-2 RNA Levels Using a Tailor-Made Oligonucleotide-Based RNA Inhibitor

V Nemethova, P Mazancova, M Selc, K Jakic… - Viruses, 2022 - mdpi.com
In only two years, the coronavirus disease 2019 (COVID-19) pandemic has had a
devastating effect on public health all over the world and caused irreparable economic …

Comparative impact of repositioned anticancer therapies on non-cancer COVID-19 patient treatment: A systematic review and network meta-analysis of randomized …

H Ja-Young, JH Kwon, DH Kim… - International Journal of …, 2023 - search.proquest.com
Purpose: Coronavirus disease 2019 (COVID-19) has emerged as a serious threat to public
health; anticancer-repositioning treatment strategy has been formulated to treat the disease …

COVID-19 scenario and recommendations on the continuity of immunobiological therapy in patients with atopic asthma in Brazil and Latin America

R de Oliveira Resende, V José de Oliveira… - Expert Review of …, 2022 - Taylor & Francis
Introduction With the abrupt establishment of the COVID-19 pandemic, treatment for
immunological diseases may be influenced by the SARS-CoV-2 infection. Immunobiologics …

Persistent Hypoxemia and Biomarkers in Severe COVID-19 Pneumonia Patients Treated with Methylprednisolone

RC Go, AP Stoffan, T Nyirenda - 2023 - researchsquare.com
Abstract Despite corticosteroids, biomarkers, SpO 2/FiO 2, and racial/ethnic groups have
been associated with mortality in Severe COVID-19 Pneumonia. This is a secondary …