Background The clinical high‐risk state for psychosis (CHR‐P) paradigm has facilitated the
implementation of psychosis prevention into clinical practice; however, advancements in …

Intervention at the earliest illness stage, in ultra or clinical high-risk individuals, or indicated
prevention, currently represents the most promising strategy to ameliorate, delay or prevent …

The “at risk mental state” for psychosis approach has been a catalytic, highly productive
research paradigm over the last 25 years. In this paper we review that paradigm and …

The introduction of clinical criteria for the operationalization of psychosis high risk provided a
basis for early detection and treatment of vulnerable individuals. However, about two-thirds …

Background Research on patients at clinical high risk (CHR) for psychosis has so far mainly
focused on those with transition to frank psychosis (CHR-T patients). However, the majority …

Prediction and prevention of negative clinical and functional outcomes represent the two
primary objectives of research conducted within the clinical high-risk for psychosis (CHR-P) …

Importance Leveraging the dynamic nature of clinical variables in the clinical high risk for
psychosis (CHR-P) population has the potential to significantly improve the performance of …

Objective Disorganization is a core dimension of schizophrenia, yet it is relatively under-
investigated compared to positive and negative ones, especially at the illness onset. Indeed …

Alterations in fMRI-based brain functional network connectivity (FNC) are associated with
schizophrenia (SCZ) and the genetic risk or subthreshold clinical symptoms preceding the …

Objective: The authors sought to characterize differences in outcomes among help-seeking
individuals at clinical high risk for psychosis by identifying covariant longitudinal patterns of …