The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that can be
activated by structurally diverse compounds arising from the environment and the microbiota …

The intestinal epithelium senses nutritional and microbial stimuli using epithelial sensory
enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous …

Tumors display increased uptake and processing of nutrients to fulfill the demands of rapidly
proliferating cancer cells. Seminal studies have shown that the proto-oncogene MYC …

The arylhydrocarbon receptor (AHR) is a ligand activated transcription factor that controls
the expression of a number of immunosuppressive signaling molecules, including the …

Zika virus (ZIKV) is a flavivirus linked to multiple birth defects including microcephaly, known
as congenital ZIKV syndrome. The identification of host factors involved in ZIKV replication …

Skin colonization by Staphylococcus aureus and its relative abundance is associated with
atopic dermatitis (AD) disease severity and treatment response. Low levels of antimicrobial …

The human aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is a
pivotal regulator of human physiology and pathophysiology. Allosteric inhibition of AhR was …

Background Self-renewing, chemoresistant breast cancer stem cells are believed to
contribute significantly to cancer invasion, migration and patient relapse. Therefore, the …

Acute myeloid leukemia (AML) can evade the mouse and human innate immune system by
suppressing natural killer (NK) cell development and NK cell function. This is driven in part …

Background: Previous studies demonstrated that coplanar polychlorinated biphenyls (PCBs)
promote proinflammatory gene expression in adipocytes. PCBs are highly lipophilic and …