Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Kaempferol (KPF) is a flavonoid antioxidant found in fruits and vegetables. Many studies
have described the beneficial effects of dietary KPF in reducing the risk of chronic diseases …

In addition to ATP synthesis, mitochondria are highly dynamic organelles that modulate
apoptosis, ferroptosis, and inflammasome activation. Through executing these varied …

Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and
subsequent lipid peroxidation. Currently, the therapeutic role of ferroptosis on cancer is …

INTRODUCTION Parkinson's disease (PD) is the second most common neurodegenerative
disorder. Intracellular protein aggregates composed primarily of α-synuclein lead to …

Parthanatos-associated apoptosis-inducing factor (AIF) nuclease (PAAN), also known as
macrophage migration inhibitor factor (MIF), is a member of the PD-D/E (X) K nucleases that …

Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

Stroke is the leading cause of death and physical disability worldwide. Mitochondrial
dysfunction has been considered as one of the hallmarks of ischemic stroke and contributes …

The NLRP3 inflammasome signaling pathway is a major contributor to the
neuroinflammatory process in the central nervous system. Oxidative stress and …