At least half of all patients with heart failure (HF) are affected by frailty, a syndrome that limits
an individual ability to recover from acute stressors. While frailty affects up to 90% of patients …

Frailty is a global health problem that impacts clinical practice. It is complex, having a
physical and a cognitive component, and it is the result of many contributing factors. Frail …

OBJECTIVE To evaluate the comparative cardiovascular effectiveness and safety of sodium–
glucose cotransporter 2 inhibitors (SGLT-2is), glucagon-like peptide 1 receptor agonists …

Background A sizeable proportion of patients with chronic kidney disease (CKD) are
reported to be frail. Here we examined the safety and efficacy of dapagliflozin in patients …

Abstract Background and Aims There is little information on the incremental prognostic
importance of frailty beyond conventional prognostic variables in heart failure (HF) …

Background: Current prevalence estimates of heart failure (HF) are primarily based on self-
report or HF hospitalizations. There is an unmet need to define the prevalence and …

Background Whether frailty influences the initiation of two cardioprotective diabetes drug
therapies (ie, SGLT2 inhibitors and GLP-1 receptor agonists) in people with type 2 diabetes …

Abstract Purpose of Review The goal of the narrative review is to provide an overview of the
epidemiology of frailty in cardiovascular disease and cardiovascular mortality and discuss …

Type 2 diabetes mellitus (T2DM) is a highly prevalent health condition in the aging
population. Older adults with T2DM have higher risks of cardiovascular disease, heart failure …

Background Frailty is increasingly recognized as a useful measure of vulnerability in older
adults. Multiple claims-based frailty indices (CFIs) can readily identify individuals with frailty …