Recent advancements in the production, modification, and cellular delivery of RNA
molecules facilitated the expansion of RNA-based therapeutics. The increasing …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

Human papillomavirus (HPV), a common sexually transmitted virus infecting mucosal or
cutaneous stratified epithelia, is implicated in the rising of associated cancers worldwide …

Colorectal cancer (CRC) affects 1 in 23 males and 1 in 25 females, making it the third most
common cancer. With roughly 608000 deaths worldwide, CRC accounts for 8% of all cancer …

Gene therapy, as an emerging therapeutic approach, has shown remarkable advantages in
the treatment of some major diseases. With the deepening of genomics research, people …

Within the tumor microenvironment (TME), regulatory T cells (Tregs) play a key role in
suppressing anticancer immune responses; therefore, various strategies targeting Tregs are …

RNA-based therapeutics have shown great promise in various medical applications,
including cancers, infectious diseases, and metabolic diseases. The recent success of …

Ribonucleic acid (RNA) therapeutics are being actively researched as a therapeutic
modality in preclinical and clinical studies. They have become one of the most ubiquitously …

Nucleic acid-based therapeutics that control gene expression have been steadily
progressing towards achieving their full clinical potential throughout the last few decades …

Immune‐mediated diseases (IMDs) are chronic conditions that have an immune‐mediated
etiology. Clinically, these diseases appear to be unrelated, but pathogenic pathways have …