Advances in single-cell RNA sequencing and its applications in cancer research

D Huang, N Ma, X Li, Y Gou, Y Duan, B Liu… - Journal of hematology & …, 2023 - Springer
Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

Spatial transcriptomics: technical aspects of recent developments and their applications in neuroscience and cancer research

HE Park, SH Jo, RH Lee, CP Macks, T Ku… - Advanced …, 2023 - Wiley Online Library
Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation
of the spatial localization of transcripts and related analyses in various applications for …

Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment

H Luo, X Xia, LB Huang, H An, M Cao, GD Kim… - Nature …, 2022 - nature.com
Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor
microenvironment (TME) and influence cancer hallmarks, but without systematic …

From immunology to artificial intelligence: revolutionizing latent tuberculosis infection diagnosis with machine learning

LS Li, L Yang, L Zhuang, ZY Ye, WG Zhao… - Military Medical …, 2023 - Springer
Latent tuberculosis infection (LTBI) has become a major source of active tuberculosis (ATB).
Although the tuberculin skin test and interferon-gamma release assay can be used to …

Spatial transcriptomics: recent developments and insights in respiratory research

WJ Wang, LX Chu, LY He, MJ Zhang, KT Dang… - Military Medical …, 2023 - Springer
The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …

Understanding cervical cancer at single-cell resolution

S Yue, Q Wang, J Zhang, Q Hu, C Liu - Cancer Letters, 2023 - Elsevier
Cervical cancer is now the fourth most prevalent malignancy in women worldwide,
representing a tremendous burden of cancer. The heterogeneity of complex tumor …

Single-cell sequencing technology applied to epigenetics for the study of tumor heterogeneity

Y Hu, F Shen, X Yang, T Han, Z Long, J Wen… - Clinical …, 2023 - Springer
Background Previous studies have traditionally attributed the initiation of cancer cells to
genetic mutations, considering them as the fundamental drivers of carcinogenesis. However …

Single‐Nucleus Transcriptome Profiling of Locally Advanced Cervical Squamous Cell Cancer Identifies Neural‐Like Progenitor Program Associated with the Efficacy …

L Zhang, J Ma, D Zhou, J Zhou, B Hu, X Ma… - Advanced …, 2023 - Wiley Online Library
Radiotherapy is the first‐line treatment for locally advanced cervical squamous cell cancer
(CSCC). However,≈ 50% of patients fail to respond to therapy and, in some cases, tumors …

Comparative analysis of single-cell transcriptome reveals heterogeneity in the tumor microenvironment of lung adenocarcinoma and brain metastases

J Liang, R Liang, K Lei, J Huang, H Lin, M Wang - Discover Oncology, 2023 - Springer
Purpose Solid tumors such as lung adenocarcinoma include not only the tumor cells but
also the microenvironment in which the tumor cells continuously interact with each other. An …

Natural products and derivatives in renal, urothelial and testicular cancers: targeting signaling pathways and therapeutic potential

D Li, J Wang, Z Tuo, KH Yoo, Q Yu, A Miyamoto… - Phytomedicine, 2024 - Elsevier
Background: Natural products have demonstrated significant potential in cancer drug
discovery, particularly in renal cancer (RCa), urothelial carcinoma (UC), and testicular …