[HTML][HTML] An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis
F Zhang, X Guo, Y Xia, L Mao - Cellular and Molecular Life Sciences, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are involved in phenotypic switching in
atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and …
atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and …
LncRNAs in vascular biology and disease
Accumulating studies indicate that long non-coding RNAs (lncRNAs) play important roles in
the regulation of diverse biological processes involved in homeostatic control of the vessel …
the regulation of diverse biological processes involved in homeostatic control of the vessel …
CARMN Is an Evolutionarily Conserved Smooth Muscle Cell–Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin
Background: Vascular homeostasis is maintained by the differentiated phenotype of
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …
The human-specific and smooth muscle cell-enriched LncRNA SMILR promotes proliferation by regulating mitotic CENPF mRNA and drives cell-cycle progression …
AD Mahmoud, MD Ballantyne, V Miscianinov… - Circulation …, 2019 - Am Heart Assoc
Rationale: In response to blood vessel wall injury, aberrant proliferation of vascular smooth
muscle cells (SMCs) causes pathological remodeling. However, the controlling mechanisms …
muscle cells (SMCs) causes pathological remodeling. However, the controlling mechanisms …
[HTML][HTML] LncRNA ANRIL acts as a modular scaffold of WDR5 and HDAC3 complexes and promotes alteration of the vascular smooth muscle cell phenotype
C Zhang, S Ge, W Gong, J Xu, Z Guo, Z Liu, X Gao… - Cell death & …, 2020 - nature.com
Many studies have shown that long-noncoding RNA (lncRNA) is associated with
cardiovascular disease, but its molecular mechanism is still unclear. In this study, we …
cardiovascular disease, but its molecular mechanism is still unclear. In this study, we …
Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells
In response to vascular injury, vascular smooth muscle cells (VSMCs) may switch from a
contractile to a proliferative phenotype thereby contributing to neointima formation. Previous …
contractile to a proliferative phenotype thereby contributing to neointima formation. Previous …
Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics
Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …
A Novel Angiotensin II–Induced Long Noncoding RNA Giver Regulates Oxidative Stress, Inflammation, and Proliferation in Vascular Smooth Muscle Cells
Rationale: AngII (angiotensin II)-mediated vascular smooth muscle cell (VSMC) dysfunction
plays a major role in hypertension. Long noncoding RNAs have elicited much interest, but …
plays a major role in hypertension. Long noncoding RNAs have elicited much interest, but …
[HTML][HTML] Emerging role of long non-coding RNAs in diabetic vascular complications
VS Tanwar, MA Reddy, R Natarajan - Frontiers in endocrinology, 2021 - frontiersin.org
Chronic metabolic disorders such as obesity and diabetes are associated with accelerated
rates of macrovascular and microvascular complications, which are leading causes of …
rates of macrovascular and microvascular complications, which are leading causes of …
Role of flow-sensitive microRNAs and long noncoding RNAs in vascular dysfunction and atherosclerosis
Atherosclerosis is the primary underlying cause of myocardial infarction, ischemic stroke,
and peripheral artery disease. The disease preferentially occurs in arterial regions exposed …
and peripheral artery disease. The disease preferentially occurs in arterial regions exposed …