[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?
CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …
first-choice drug used daily by approximately 150 million people. An accumulation of …
Reactive oxygen species (ROS) in macrophage activation and function in diabetes
E Rendra, V Riabov, DM Mossel, T Sevastyanova… - Immunobiology, 2019 - Elsevier
In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …
Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
[HTML][HTML] Metformin treatment was associated with decreased mortality in COVID-19 patients with diabetes in a retrospective analysis
P Luo, L Qiu, Y Liu, X Liu, J Zheng, H Xue… - The American journal …, 2020 - ncbi.nlm.nih.gov
Metformin was proposed to be a candidate for host-directed therapy for COVID-19. However,
its efficacy remains to be validated. In this study, we compared the outcome of metformin …
its efficacy remains to be validated. In this study, we compared the outcome of metformin …
[HTML][HTML] The effects of metformin on autophagy
G Lu, Z Wu, J Shang, Z Xie, C Chen - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Metformin is the first-line option for treating newly diagnosed diabetic patients and also
involved in other pharmacological actions, including antitumor effect, anti-aging effect …
involved in other pharmacological actions, including antitumor effect, anti-aging effect …
[HTML][HTML] Metformin, macrophage dysfunction and atherosclerosis
Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …
treat many diseases. More and more evidence shows that metformin can regulate the …
[HTML][HTML] Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing
Coronavirus Disease 2019 (COVID-19), caused by a new strain of coronavirus called
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared a …
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared a …
[HTML][HTML] Metformin induces the M2 macrophage polarization to accelerate the wound healing via regulating AMPK/mTOR/NLRP3 inflammasome singling pathway
L Qing, J Fu, P Wu, Z Zhou, F Yu… - American journal of …, 2019 - ncbi.nlm.nih.gov
Background: Skin wound healing is a challenging problem, especially in aging or diabetic
patients, which becomes more difficult to heal, and easily results in considerable public …
patients, which becomes more difficult to heal, and easily results in considerable public …
[HTML][HTML] Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential
The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has become a serious
challenge for medicine and science. Analysis of the molecular mechanisms associated with …
challenge for medicine and science. Analysis of the molecular mechanisms associated with …
[HTML][HTML] Gestational diabetes mellitus and maternal immune dysregulation: what we know so far
Gestational diabetes mellitus (GDM) is an obstetric complication that affects approximately 5–
10% of all pregnancies worldwide. GDM is defined as any degree of glucose intolerance …
10% of all pregnancies worldwide. GDM is defined as any degree of glucose intolerance …