Drug delivery to the central nervous system

E Nance, SH Pun, R Saigal, DL Sellers - Nature Reviews Materials, 2022 - nature.com
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

[HTML][HTML] Blood–brain barrier dynamics to maintain brain homeostasis

M Segarra, MR Aburto, A Acker-Palmer - Trends in neurosciences, 2021 - cell.com
The blood–brain barrier (BBB) is a dynamic platform for exchange of substances between
the blood and the brain parenchyma, and it is an essential functional gatekeeper for the …

The transition to motherhood: linking hormones, brain and behaviour

C Servin-Barthet, M Martínez-García, C Pretus… - Nature Reviews …, 2023 - nature.com
We are witnessing a stark increase in scientific interest in the neurobiological processes
associated with pregnancy and maternity. Convergent evidence suggests that around the …

Brain penetrating peptides and peptide–drug conjugates to overcome the blood–brain barrier and target CNS diseases

X Zhou, QR Smith, X Liu - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …

Progesterone in the brain: hormone, neurosteroid and neuroprotectant

R Guennoun - International journal of molecular sciences, 2020 - mdpi.com
Progesterone has a broad spectrum of actions in the brain. Among these, the
neuroprotective effects are well documented. Progesterone neural effects are mediated by …

Customizing delivery nano-vehicles for precise brain tumor therapy

YB Miao, W Zhao, G Renchi, Y Gong, Y Shi - Journal of …, 2023 - Springer
Although some tumor has become a curable disease for many patients, involvement of the
central nervous system (CNS) is still a major concern. The blood–brain barrier (BBB), a …

The role of androgens in women's health and wellbeing

VE Bianchi, E Bresciani, R Meanti, L Rizzi… - Pharmacological …, 2021 - Elsevier
Androgens in women, as well as in men, are intrinsic to maintenance of (i) reproductive
competency,(ii) cardiac health,(iii) appropriate bone remodeling and mass retention,(iii) …

Stress hormones in psychophysiological research: emotional, behavioral, and cognitive implications.

WR Lovallo, TW Buchanan - 2017 - psycnet.apa.org
This chapter describes regulation of the stress hormones and their measurement and
interpretation in psychophysiological research. A hormone is a signaling molecule, secreted …

Physiological effect of ghrelin on body systems

Y Akalu, MD Molla, G Dessie… - International journal of …, 2020 - Wiley Online Library
Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of
physiological effects. In this review, we found/confirmed that ghrelin has effect on all body …