Analysis and interpretation of studies on cognitive and affective dysregulation often draw
upon the network paradigm, especially the Triple Network Model, which consists of the …

Background Childhood maltreatment is the most important preventable cause of
psychopathology accounting for about 45% of the population attributable risk for childhood …

The relationship between the conscious experience of physical symptoms and indicators of
objective physiological dysfunction is highly variable and depends on characteristics of the …

Despite long-standing interest in the influence of adverse early experiences on mental
health, systematic scientific inquiry into childhood adversity and developmental outcomes …

We propose a taxonomy of psychopathology based on patterns of shared causal influences
identified in a review of multivariate behavior genetic studies that distinguish genetic and …

Supported by recent human neuroimaging studies, the insula is re-emerging as an important
brain area not only in the physiological understanding of the brain, but also in pathological …

The science of large-scale brain networks offers a powerful paradigm for investigating
cognitive and affective dysfunction in psychiatric and neurological disorders. This review …

In this article, we provide a fresh perspective on the developmental origins of neuroticism—a
dimension of temperament marked by elevated stress reactivity resulting in the frequent …

Objective The aims of this study were 2-fold: to provide a brief introduction to the prospective
longitudinal Great Smoky Mountains Study and review recent findings; and to use this …

Disrupted interoception is a prominent feature of the diagnostic classification of several
psychiatric disorders. However, progress in understanding the interoceptive basis of these …