The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder

KA Jellinger - Journal of Neural Transmission, 2023 - Springer
Depression is frequent in older individuals and is often associated with cognitive impairment
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …

[HTML][HTML] MRI predictors of pharmacotherapy response in major depressive disorder

AR Gerlach, HT Karim, M Pecina, O Ajilore… - NeuroImage: Clinical, 2022 - Elsevier
Major depressive disorder is among the most prevalent psychiatric disorders, exacting a
substantial personal, social, and economic toll. Antidepressant treatment typically involves …

[HTML][HTML] Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report

PL Ballester, JS Suh, N Nogovitsyn, S Hassel… - NeuroImage: Clinical, 2021 - Elsevier
Objectives Previous studies suggest that major depressive disorder (MDD) may be
associated with volumetric indications of accelerated brain aging. This study investigated …

Gray matter biomarkers for major depressive disorder and manic disorder using logistic regression

M Kumar, P Goyal, R Sagar, SS Kumaran - Journal of psychiatric research, 2024 - Elsevier
The study investigates morphometric changes using surface-based measures and logistic
regression in Major depressive-disorder (MDD) and Manic-disorder patients as compared to …

Voxel-based asymmetry of the regional gray matter over the inferior temporal gyrus correlates with depressive symptoms in medicated patients with major depressive …

K Kocsis, A Holczer, C Kazinczi, K Boross… - Psychiatry Research …, 2021 - Elsevier
The number of patients suffering from major depressive disorder (MDD) is increasing
worldwide. Imbalanced hemispherical brain activity may be an underlying factor of MDD; …

Region‐specific associations between gamma‐aminobutyric acid A receptor binding and cortical thickness in high‐functioning autistic adults

D James, VT Lam, B Jo, LK Fung - Autism Research, 2022 - Wiley Online Library
The neurobiology of autism has been shown to involve alterations in cortical morphology
and gamma‐aminobutyric acid A (GABAA) receptor density. We hypothesized that GABAA …

[HTML][HTML] Hypothalamus volume and DNA methylation of stress axis genes in major depressive disorder: A CAN-BIND study report

JS Suh, LM Fiori, M Ali, KL Harkness… - …, 2021 - Elsevier
Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is considered one of the
mechanisms underlying the development of major depressive disorder (MDD), but the exact …

Cortical thickness predicts response following 2 weeks of SSRI regimen in first-episode, drug-naive major depressive disorder: an MRI study

P Wu, A Zhang, N Sun, L Lei, P Liu, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Objective Major depression disorder (MDD) is a harmful disorder, and the pathological
mechanism remains unclear. The primary pharmacotherapy regimen for MDD is selective …

Distinct and shared patterns of brain plasticity during electroconvulsive therapy and treatment as usual in depression: an observational multimodal MRI-study

T Bracht, S Walther, S Breit, N Mertse… - Translational …, 2023 - nature.com
Electroconvulsive therapy (ECT) is a highly effective treatment for depression. Previous
studies point to ECT-induced volume increase in the hippocampi and amygdalae, and to …

Shared genetic architecture of cortical thickness alterations in major depressive disorder and schizophrenia

H Wang, Q Zhao, Y Zhang, J Ma, M Lei, Z Zhang… - Progress in Neuro …, 2024 - Elsevier
Background Major depressive disorder (MDD) and schizophrenia (SCZ) are heritable brain
disorders characterized by alterations in cortical thickness. However, the shared genetic …