Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …

The prevalence of neurodegenerative disease (ND) is increasing, partly owing to extensions
in lifespan, with a larger percentage of members living to an older age, but the ND aetiology …

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with ill-defined
pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we …

Neurodegenerative diseases (NDDs) significantly contribute to morbidity and mortality
worldwide. The suboptimal effect of currently used therapeutic approaches administered via …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substantia nigra pars compacta, leading to motor …

Overlapping symptoms and co-pathologies are common in closely related
neurodegenerative diseases (NDDs). Investigating genetic risk variants across these NDDs …

Huntington's disease (HD) is a chronic neurodegenerative disorder caused by an expansion
of polyglutamine repeats in exon 1 of the Huntingtin gene. Transcriptional dysregulation …

Na+/K+-ATPase (NKA), a large transmembrane protein, is expressed in the plasma
membrane of most eukaryotic cells. It maintains resting membrane potential, cell volume and …

Neurodegenerative disorders (NDs) lead to the progressive degeneration of the structural
and physiological functions of the central and peripheral nervous systems, resulting in …

Traumatic brain injury (TBI) initiates tissue and cellular damage to the brain that is
immediately followed by secondary injury sequalae with delayed and continual damage …