Climate change poses a serious threat to human health worldwide, while aging populations
increase. However, no study has ever investigated the effects of air temperature on …

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, the underlying
pathological mechanisms of which are not yet completely understood. Although several …

DNA methylation (DNAm) overwrites information about multiple extrinsic factors on the
genome. Age is one of these factors. Age causes characteristic DNAm changes that are …

Background Individuals who are socioeconomically disadvantaged are at increased risk for
aging-related diseases and perform less well on tests of cognitive function. The weathering …

Background and Objectives In multiple sclerosis (MS), accelerated aging of the immune
system (immunosenescence) may be associated with disease onset or drive progression …

Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …

Individuals with psychiatric disorders are at increased risk of age-related diseases and early
mortality. Recent studies demonstrate that this link between mental health and aging is …

Background There is evidence that complex diseases and mortality are associated with DNA
methylation (DNAm) and age acceleration. Numerous epigenetic clocks, including Horvath …

OBJECTIVE We examined whether relative availability of fast-food restaurants and
supermarkets mediates the association between worse neighborhood socioeconomic …

We explore how functional genomics approaches that integrate datasets from human and
non-human model systems can improve our understanding of the effect of gene …