Susceptibility to many human autoimmune diseases is under strong genetic control by class
II human leukocyte antigen (HLA) allele combinations. These genes remain by far the …

OBJECTIVE To distinguish among predictors of seroconversion, progression to multiple
autoantibodies and from multiple autoantibodies to type 1 diabetes in young children …

Type 1 Diabetes (T1D) is one of the most common chronic autoimmune diseases in children.
The disease is characterized by the destruction of beta cells, leading to hyperglycemia, and …

Abstract Background Type 1 diabetes (T1D) results from immune-mediated destruction of
insulin-producing beta cells. Prevention efforts have focused on immune modulation and …

Abstract Purpose of Review The environmental triggers of islet autoimmunity leading to type
1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental …

Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

Islet autoantibodies are key markers for the diagnosis of type 1 diabetes. Since their
discovery, they have also been recognized for their potential to identify at-risk individuals …

OBJECTIVE To evaluate the efficacy of aluminum-formulated intralymphatic glutamic acid
decarboxylase (GAD-alum) therapy combined with vitamin D supplementation in preserving …

Aims/hypothesis Young children who develop multiple autoantibodies (mAbs) are at very
high risk for type 1 diabetes. We assessed whether a population with mAbs detected by …

OBJECTIVE Assessment of the predictive power of The Environmental Determinants of
Diabetes in the Young (TEDDY)-identified risk factors for islet autoimmunity (IA), the type of …