Abstract Background Type 1 diabetes (T1D) results from immune-mediated destruction of
insulin-producing beta cells. Prevention efforts have focused on immune modulation and …

Abstract 'The clock to type 1 diabetes has started when islet antibodies are first detected',
commented George Eisenbarth with regard to the pathogenesis of type 1 diabetes. This …

Type 1 diabetes (T1D) is classically characterised by the clinical need for insulin, the
presence of disease-associated serum autoantibodies, and an onset in childhood. The …

Microencapsulation of polyherbal formulation (PHF) extract was carried out by freeze drying
method, by employing gum arabic (GA), gelatin (GE), and maltodextrin (MD) with their …

Viruses are postulated as primary candidate triggers of islet autoimmunity (IA) and type 1
diabetes (T1D), based on considerable epidemiological and experimental evidence. Recent …

The present work was designed to investigate the antihyperglycaemic and protective effects
of two Hericium erinaceus intracellular polysaccharide (HIPS) purified fractions (HIPS1 and …

OBJECTIVE Environmental microbial exposures have been implicated to protect against
immune-mediated diseases such as type 1 diabetes. Our objective was to study the …

OBJECTIVE To investigate gastrointestinal infection episodes (GIEs) in relation to the
appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which pancreatic islet β cells are
destroyed by immune cells, ultimately leading to overt diabetes. The progressive increase in …

Traditional linkage analysis and genome-wide association studies have identified HLA and
a number of non-HLA genes as genetic factors for islet autoimmunity (IA) and type 1 …