[HTML][HTML] New horizons in the treatment of type 1 diabetes: more intense immunosuppression and beta cell replacement
CEB Couri, KCR Malmegrim, MC Oliveira - Frontiers in immunology, 2018 - frontiersin.org
Since the discovery of autoimmunity as the main pathophysiologic process involved in type
1 diabetes, many attempts have tried to delay or stop beta cell destruction. Most research …
1 diabetes, many attempts have tried to delay or stop beta cell destruction. Most research …
Autoimmune (Type 1) diabetes
Abstract Type 1 diabetes (T1D), also known as autoimmune diabetes or insulin-dependent
diabetes mellitus, is a chronic autoimmune disease, in which pancreatic beta cells are …
diabetes mellitus, is a chronic autoimmune disease, in which pancreatic beta cells are …
[HTML][HTML] Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample
NG Bediaga, CSN Li-Wai-Suen, MJ Haller… - Diabetologia, 2021 - Springer
Aims/hypothesis Accurate prediction of disease progression in individuals with pre-
symptomatic type 1 diabetes has potential to prevent ketoacidosis and accelerate …
symptomatic type 1 diabetes has potential to prevent ketoacidosis and accelerate …
Reduction in white blood cell, neutrophil, and red blood cell counts related to sex, HLA, and islet autoantibodies in Swedish TEDDY children at increased risk for type …
F Salami, HS Lee, E Freyhult, H Elding Larsson… - Diabetes, 2018 - Am Diabetes Assoc
Islet autoantibodies (IAs) precede the clinical onset of type 1 diabetes (T1D); however, the
knowledge is limited about whether the prodrome affects complete blood counts (CBCs) in 4 …
knowledge is limited about whether the prodrome affects complete blood counts (CBCs) in 4 …
[HTML][HTML] Influence of early-life parental severe life events on the risk of type 1 diabetes in children: the DiPiS study
M Lundgren, K Ellström, H Elding Larsson - Acta diabetologica, 2018 - Springer
Aims Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here,
we aimed to establish if SLEs reported by parents during the first 2 years of life influence the …
we aimed to establish if SLEs reported by parents during the first 2 years of life influence the …
Islet autoantibody types mark differential clinical characteristics at diagnosis of pediatric type 1 diabetes
J Nieto, B Castillo, M Astudillo, M Tosur… - Pediatric …, 2021 - Wiley Online Library
Background We aimed to study whether islet autoantibody type marks differential
characteristics at the time of type 1 diabetes (T1D) diagnosis. Methods We studied 711 …
characteristics at the time of type 1 diabetes (T1D) diagnosis. Methods We studied 711 …
Heterogeneity of DKA incidence and age-specific clinical characteristics in children diagnosed with type 1 diabetes in the TEDDY study
LM Jacobsen, K Vehik, R Veijola, K Warncke… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE The Environmental Determinants of Diabetes in the Young (TEDDY) study is
uniquely capable of investigating age-specific differences associated with type 1 diabetes …
uniquely capable of investigating age-specific differences associated with type 1 diabetes …
Analysis of chosen polymorphisms rs2476601 a/G–PTPN22, rs1990760 C/T–IFIH1, rs179247 a/G–TSHR in pathogenesis of autoimmune thyroid diseases in children
M Rydzewska, A Góralczyk, J Gościk… - …, 2018 - Taylor & Francis
Background: Autoimmune thyroid diseases are multifactorial diseases with a genetic
susceptibility and environmental factors. A potential role of the protein tyrosine phosphatase …
susceptibility and environmental factors. A potential role of the protein tyrosine phosphatase …
[PDF][PDF] A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes
Circulating microRNAs (miRNAs) are linked to the onset and progression of type 1 diabetes
mellitus (T1DM), thus representing potential disease biomarkers. In this study, we employed …
mellitus (T1DM), thus representing potential disease biomarkers. In this study, we employed …
Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A* 24 and-B* 18 Is Restricted to Multiple Islet Autoantibody–Positive Individuals With Distinct HLA …
EM Balke, EV Balti, B Van der Auwera, I Weets… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE We investigated the effect of HLA class I risk alleles on disease progression in
various phases of subclinical islet autoimmunity in first-degree relatives of patients with type …
various phases of subclinical islet autoimmunity in first-degree relatives of patients with type …