The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of
contents from the intestinal lumen into the intestinal tissue and systemic circulation. A …

Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the
interaction of genetic, environmental, barrier and microbial factors leading to chronic …

Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence
worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and …

Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA)
oxidation, progresses to non-alcoholic steatohepatitis (NASH) on stress and inflammation. A …

The importance of gut microbiota in human health and pathophysiology is undisputable.
Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in …

Abstract Rationale: Ulcerative colitis (UC), a typical kind of inflammatory bowel disease
(IBD), is an idiopathic chronic intestinal inflammation. Conventional therapeutic strategies …

Polyphenols, including phenolic acids, flavonoids, and procyanidins, are abundant in food
and beverage derived from plants. Tea (Camellia sinensis) is particularly rich in polyphenols …

Simple Summary The gastrointestinal tract is a complex organization of various types of
epithelial cells forming a single layer of the mucosal barrier, the host mucosal immune …

The intestinal mucosa exists in dynamic balance with trillions of luminal microbes. Disruption
of the intestinal epithelial barrier, commonly observed in mucosal inflammation and …

Inflammatory bowel disease (IBD) pathogenesis is associated with gut mucosal
inflammation, epithelial damage, and dysbiosis leading to a dysregulated gut mucosal …