Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …

Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

Joint profiling of chromatin accessibility and gene expression from the same single cell
provides critical information about cell types in a tissue and cell states during a dynamic …

Single-cell omics sequencing was first achieved for the transcriptome in 2009, which was
followed by fast development of technologies for profiling the genome, DNA methylome, 3D …

Pancreatic cancer is a highly aggressive malignancy with a climbing incidence. The majority
of cases are detected late, with incurable locally advanced or metastatic disease. Even in …

Single-cell omics technologies have revolutionized molecular profiling by providing high-
resolution insights into cellular heterogeneity and complexity. Traditional bulk omics …

Understanding clonal evolution and cancer development requires experimental approaches
for characterizing the consequences of somatic mutations on gene regulation. However, no …

With the rapid advance of single-cell sequencing technology, cell heterogeneity in various
biological processes was dissected at different omics levels. However, single-cell mono …

Recently, immunotherapy has gained increasing popularity in oncology. Several
immunotherapies obtained remarkable clinical effects, but the efficacy varied, and only …

Single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) is
rapidly becoming a powerful technology for assessing the epigenetic landscape of …