[HTML][HTML] Niclosamide as a promising therapeutic player in human cancer and other diseases

Z Wang, J Ren, J Du, H Wang, J Liu… - International Journal of …, 2022 - mdpi.com
Niclosamide is an FDA-approved anthelmintic drug for the treatment of parasitic infections.
However, over the past few years, increasing evidence has shown that niclosamide could …

[HTML][HTML] On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

RL Carvalho, AS de Miranda… - Beilstein Journal of …, 2021 - beilstein-journals.org
Several valuable biologically active molecules can be obtained through C–H activation
processes. However, the use of expensive and not readily accessible catalysts complicates …

Virus-like plasmonic nanoprobes for quick analysis of antiviral efficacy and mutation-induced drug resistance

Y Ouyang, Y Chen, J Shang, S Sun, X Wang… - Analytical …, 2023 - ACS Publications
As the pathogenic viruses and the variants of concern greatly threaten human health and
global public safety, the development of convenient and robust strategies enabling rapid …

[HTML][HTML] Human Wharton's jelly mesenchymal stem cells secretome inhibits human SARS-CoV-2 and avian infectious bronchitis coronaviruses

MAA Hussein, HAM Hussein, AA Thabet, KM Selim… - Cells, 2022 - mdpi.com
Human SARS-CoV-2 and avian infectious bronchitis virus (IBV) are highly contagious and
deadly coronaviruses, causing devastating respiratory diseases in humans and chickens …

[HTML][HTML] A computational study of potential therapeutics for COVID-19 invoking conceptual density functional theory

Saloni, D Kumari, P Ranjan, T Chakraborty - Structural Chemistry, 2022 - Springer
Abstract The pandemic, COVID-19, has caused social and economic disruption at a larger
pace all over the world. Identification of an effective drug for the deadliest disease is still an …

[HTML][HTML] Potent antiviral activity of vitamin B12 against severe acute respiratory syndrome coronavirus 2, middle east respiratory syndrome coronavirus, and human …

Y Moatasim, O Kutkat, AM Osman, MR Gomaa, F Okda… - Microorganisms, 2023 - mdpi.com
Repurposing vitamins as antiviral supporting agents is a rapid approach used to control
emerging viral infections. Although there is considerable evidence supporting the use of …

[HTML][HTML] The pH dependence of niclosamide solubility, dissolution, and morphology: motivation for potentially universal mucin-penetrating nasal and throat sprays for …

D Needham - Pharmaceutical research, 2022 - Springer
Motivation With the coronavirus pandemic still raging, prophylactic-nasal and early-
treatment throat-sprays could help prevent infection and reduce viral load. Niclosamide has …

[HTML][HTML] Characterization, in-silico, and in-vitro study of a new steroid derivative from Ophiocoma dentata as a potential treatment for COVID-19

MSM Abd El Hafez, MG AbdEl-Wahab, MG Seadawy… - Scientific Reports, 2022 - nature.com
The medicinal potential of marine invertebrates' bioactive components that may act as anti-
COVID-19 demonstrated promising results. Ophiocoma dentata, which is common in the …

[HTML][HTML] Design and synthesis of novel 5-((3-(Trifluoromethyl) piperidin-1-yl) sulfonyl) indoline-2, 3-dione derivatives as promising Antiviral agents: in vitro, in silico …

RR Ezz Eldin, MA Saleh, SA Alwarsh, A Rushdi… - Pharmaceuticals, 2023 - mdpi.com
Herein, a series of new isatin derivatives was designed and synthesized (1–9) as broad-
spectrum antiviral agents. Consequently, the antiviral activities of the synthesized …

[HTML][HTML] In vitro assessment of the antiviral activity of ketotifen, indomethacin and naproxen, alone and in combination, against SARS-CoV-2

P Kiani, A Scholey, TA Dahl, L McMann, JM Iversen… - Viruses, 2021 - mdpi.com
The 2019 coronavirus infectious disease (COVID-19) is caused by infection with the new
severe acute respiratory syndrome coronavirus (SARS-CoV-2). Currently, the treatment …