Depression is a polygenic and highly complex psychiatric disorder that remains a major
burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) …

Serotonin regulates many physiological processes including sleep, appetite, and mood.
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …

Abstract Rationale Serotonin reuptake inhibitors (SSRIs) are effective in treating depression.
Given the existence of different families and subtypes of 5-HT receptors, multiple 5-HT …

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized
by repetitive and stereotyped behaviors as well as difficulties with social interaction and …

Long-term exposure to adverse life events that provoke acute or chronic psychological
stress (hereinafter “stress”) can negatively affect physical health and even increase …

Alzheimer's disease (AD) is one of the most frequent causes of death and disability
worldwide and has a significant clinical and socioeconomic impact. In the search for novel …

Serotonin (5-HT) plays an important role in the regulation of several basic functions of the
central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT6) …

Serotonin (5-HT) is an important player in decision making. Serotonergic antidepressant,
anxiolytic and antipsychotic drugs are extensively used in the treatment of neuropsychiatric …

Alzheimer's disease (AD) has a complex and not-fully-understood etiology. Recently, the
serotonin receptor 5-HT6 emerged as a promising target for AD treatment; thus, here a new …

Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …