Mathematical Modeling of Eicosanoid Metabolism in Macrophage Cells: Cybernetic Framework Combined with Novel Information-Theoretic Approaches

L Aboulmouna, S Khanum, M Heidari, R Raja, S Gupta… - Processes, 2023 - mdpi.com
Cellular response to inflammatory stimuli leads to the production of eicosanoids—
prostanoids (PRs) and leukotrienes (LTs)—and signaling molecules—cytokines and …

Cytotoxic T-cell-based Vaccine against SARS-CoV-2: a hybrid immunoinformatic approach

A Tîrziu, V Paunescu - Vaccines, 2022 - mdpi.com
This paper presents an alternative vaccination platform that provides long-term cellular
immune protection mediated by cytotoxic T-cells. The immune response via cellular …

Zymosan Particle-Induced Hemodynamic, Cytokine and Blood Cell Changes in Pigs: An Innate Immune Stimulation Model with Relevance to Cytokine Storm …

G Kökény, T Bakos, BA Barta, GV Nagy… - International Journal of …, 2023 - mdpi.com
Hemodynamic disturbance, a rise in neutrophil-to-lymphocyte ratio (NLR) and release of
inflammatory cytokines into blood, is a bad prognostic indicator in severe COVID-19 and …

SNP (A> G-rs13057211) but not GT (n) polymorphism in HMOX-1 promotor gene is associated with COVID-19 mortality

K Fares, MK El-Deeb, O Elsammak, A Ouf… - BMC Pulmonary …, 2023 - Springer
Introduction COVID-19 causes severe inflammatory respiratory distress syndrome. The
global pandemic caused millions of cases of morbidity and mortality worldwide. Patients …

Covid-19 in patients with haematological malignancies

H Warda, K Skórka… - Acta Haematologica …, 2024 - journals.viamedica.pl
In most cases, the COVID-19 is characterized by mild clinical course, however, there are
groups of patients at high risk of mortality and morbidity of COVID-19, including the older …

Humulus lupus extract rich in Xanthohumol reduces the risk of a fatal clinical course in critically ill patients treated for COVID-19

W Dabrowski, M Gagos, D Siwicka-Gieroba… - 2022 - researchsquare.com
Background. The systemic inflammatory response following severe coronavirus infection
(COVID-19) is associated with poor outcome. Several anti-inflammatory medications were …

theme issue on coronavirus and surfaces

M Edirisinghe OBE - Interface Focus, 2021 - royalsocietypublishing.org
Since the publication of the headline review on 'Surface interactions and viability of
coronaviruses' in Journal of the Royal Society Interface in January 2021 (https://doi …

Zymosan-induced leukocyte and cytokine changes in pigs: a new model for streamlined drug testing against severe COVID-19

G Kökény, T Bakos, BA Barta, GV Nagy, T Mészáros… - bioRxiv, 2022 - biorxiv.org
Abstract Injection of 0.1 mg/kg zymosan in pigs iv elicited transient hemodynamic
disturbance within minutes, without major blood cell changes. In contrast, infusion of 1 mg/kg …

[PDF][PDF] In Silico Analysis of Flavonoid Potential as Inhibitors of Interleukin-6 (IL-6) and Tumor Necrosis Factor-Alpha (TNF-α) in Managing Cytokine Storm

MD Hanifan, M Sariyanti, B Sinuhaji… - J Pharm Sci Drug …, 2024 - manuscriptscientific.com
Abstract Interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) exert the greatest
influence on cytokine cascades via the nuclear factor-kappa B (NF-B) and janus …

Vectorización de agentes terapéuticos a macrófagos para el tratamiento de procesos inflamatorios

MC Villa Hermosilla - 2024 - docta.ucm.es
Inflammation is an immediate and non-specific response that the body initiates when there is
a chemical, physical, or biological aggression. If the inflammation persists over time, it can …