Kidney stone disease (nephrolithiasis) is a common problem that can be associated with
alterations in urinary solute composition including hypercalciuria. Studies suggest that the …

GeoBioMed—a new transdisciplinary approach that integrates the fields of geology, biology
and medicine—reveals that kidney stones composed of calcium-rich minerals precipitate …

Obesity increases the risk of several diseases, including kidney stone disease (KSD). The
study aimed to explore the relationship between KSD and various obesity-related indices. A …

Kidney stone disease (nephrolithiasis) is a major clinical and economic health burden with a
heritability of~ 45–60%. We present genome-wide association studies in British and …

The prevalence of urolithiasis in humans is increasing worldwide; however, non-surgical
treatment and prevention options remain limited despite decades of investigation. Most …

Kidney stone disease comprising nephrolithiasis and nephrocalcinosis is a clinical
syndrome of increasing prevalence with remarkable heterogeneity. Stone composition, age …

Epidemiological evidence shows that nephrolithiasis is associated with cardiovascular (CV)
morbidities. The association between nephrolithiasis and CV disease is not surprising …

Background: Kidney stone formers (SF) are more likely to develop diabetes mellitus (DM),
but there is no study examining risk of metabolic syndrome (MetS) in this population. We …

Uterine leiomyoma is one of the most common gynaecologic benign tumours, but its genetic
basis remains largely unknown. Six previous GWAS identified 33 genetic factors in total …

Paracellular transport in the kidney is mediated by a family of proteins located in the tight
junctions called claudins which confers its ionic selectivity. Claudin-2 is highly expressed in …