Genetic and experimental evidence suggests that Alzheimer's disease (AD) risk alleles and
genes may influence disease susceptibility by altering the transcriptional and cellular …

Background Age is the strongest risk factor for the development of Alzheimer's disease (AD).
Besides the pathological hallmarks of β-amyloid (Aβ) plaques and neurofibrillary tangles …

Introduction Cholesterol homeostasis is critical for normal brain function. It is tightly
controlled by various biological elements. ATP-binding cassette transporter A1 (ABCA1) is a …

Importance Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay
along a continuum hypothesized to associate with tangle distribution and are relevant for …

Growing evidence supports the suggestion that the peripheral immune system plays a role
in different pathologies associated with cognitive impairment, such as vascular dementia …

APOE allelic variation is critical in brain aging and Alzheimer's disease (AD). The APOE2
allele associated with cognitive resilience and neuroprotection against AD remains …

The cautious optimism following recent anti-amyloid therapeutic trials for Alzheimer's
disease (AD) provides a glimmer of hope after years of disappointment. Although these …

The brains of Alzheimer's disease (AD) patients contain numerous amyloid plaques that are
diagnostic of the disease. The plaques are primarily composed of the amyloidogenic …

Alzheimer's disease (AD) is heterogenous on the molecular level. Understanding this
heterogeneity is critical for AD drug development. We aimed to define AD molecular …

Depression is a common and devastating neuropsychiatric symptom in the elderly and in
patients with dementia. In particular, nearly 80% of patients with Alzheimer's Disease …