Schizophrenia and bipolar disorder (BPD) are believed to share clinical features, etiological
factors, and disease pathologies (such as impaired cognitive functions and dendritic spine …

Several lines of evidence have suggested for decades a role for norepinephrine (NE) in the
pathophysiology and treatment of schizophrenia. Recent experimental findings reveal …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …

Background Parkinson's disease (PD) and schizophrenia (SCZ) are heritable brain
disorders that involve dysregulation of the dopaminergic system. Epidemiological studies …

Genome-wide association studies (GWAS) have identified several common genetic variants
influencing major depression and general cognitive abilities, but little is known about …

Accumulating evidence indicates systemic biological dysregulations in patients with
psychosis that have been conceptualized as the “allostatic load”(AL) index. We aimed to …

Important questions remain about the profile of cognitive impairment in psychotic disorders
across adulthood and illness stages. The age-associated profile of familial impairments also …

Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder
(ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping …

General cognitive (intelligence) function is substantially heritable, and is a major
determinant of economic and health-related life outcomes. Cognitive impairments and …

Identifying genetic contributors to cognitive impairments in psychosis-spectrum disorders
can advance understanding of disease pathophysiology. Although CNS medications are …