Background Schizophrenia commonly co-occurs with cardiometabolic and inflammation-
related traits. It is unclear to what extent the comorbidity could be explained by shared …

The primary aim of precision medicine is to tailor healthcare more closely to the needs of
individual patients. This requires progress in two areas: the development of more precise …

Schizophrenia is a multifactorial disease associated with widespread cognitive impairment.
Although cognitive deficits are one of the factors most strongly associated with functional …

Background and aim Schizophrenia (SCZ) and bipolar disorder (BD) have a high
comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol …

Cognitive impairment is a core feature of schizophrenia which precedes the onset of full
psychotic symptoms, even in the ultra-high-risk stage (UHR). Polygenic risk scores (PRS) …

Background: Alzheimer's disease (AD) and bipolar disorder (BIP) are complex traits
influenced by numerous common genetic variants, most of which remain to be detected …

Adverse Childhood Experiences are stressful and traumatic events occurring before the age
of eighteen shown to cause mental and physical health problems, including increased risk of …

Brainstem regions support vital bodily functions, yet their genetic architectures and
involvement in common brain disorders remain understudied. Here, using imaging-genetics …

Genome-wide association studies have transformed psychiatric genetics and provided novel
insights into the genetic etiology of psychiatric disorders. Two major discoveries have …

Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and
coronary artery disease (CAD). The conditional/conjunctional false discovery rate method …