[HTML][HTML] A machine learning approach to predicting autism risk genes: Validation of known genes and discovery of new candidates
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong
genetic basis. The role of de novo mutations in ASD has been well established, but the set of …
genetic basis. The role of de novo mutations in ASD has been well established, but the set of …
[HTML][HTML] What genome-wide association studies reveal about the association between intelligence and mental health
Intelligence, as measured by standardised tests of cognitive function, such as IQ-type tests,
is predictive of psychiatric diagnosis and psychological wellbeing. Using genome-wide …
is predictive of psychiatric diagnosis and psychological wellbeing. Using genome-wide …
Big data begin in psychiatry
MM Weissman - JAMA psychiatry, 2020 - jamanetwork.com
The last 40 years ofJAMA Psychiatryare reviewed as a celebration of its achievements. The
focus of this article is on the evolution of big data as reflected in key journal articles. The …
focus of this article is on the evolution of big data as reflected in key journal articles. The …
[HTML][HTML] Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems
Postmortem studies in patients with schizophrenia (SCZ) have revealed deficits in
myelination, abnormalities in myelin gene expression and altered numbers of …
myelination, abnormalities in myelin gene expression and altered numbers of …
[HTML][HTML] Sex-specific effects of polygenic risk for schizophrenia on lifespan cognitive functioning in healthy individuals
Abstract Polygenic risk for schizophrenia has been associated with lower cognitive ability
and age-related cognitive change in healthy individuals. Despite well-established …
and age-related cognitive change in healthy individuals. Despite well-established …
TCF 20 dysfunction leads to cortical neurogenesis defects and autistic‐like behaviors in mice
C Feng, J Zhao, F Ji, L Su, Y Chen, J Jiao - EMBO reports, 2020 - embopress.org
Recently, de novo mutations of transcription factor 20 (TCF 20) were found in patients with
autism by large‐scale exome sequencing. However, how TCF 20 modulates brain …
autism by large‐scale exome sequencing. However, how TCF 20 modulates brain …
[HTML][HTML] Alteration of DNA methylation and epigenetic scores associated with features of schizophrenia and common variant genetic risk
Background Unpacking molecular perturbations associated with features of schizophrenia is
a critical step toward understanding phenotypic heterogeneity in this disorder. Recent …
a critical step toward understanding phenotypic heterogeneity in this disorder. Recent …
[HTML][HTML] Meta-GWAS identifies the heritability of acute radiation-induced toxicities in head and neck cancer
Background and purpose We aimed to the genetic components and susceptibility variants
associated with acute radiation-induced toxicities (RITs) in patients with head and neck …
associated with acute radiation-induced toxicities (RITs) in patients with head and neck …
Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk
C Zhang, X Li, L Zhao, W Guo, W Deng… - Psychological …, 2023 - cambridge.org
BackgroundTo identify risk genes whose expression are regulated by the reported risk
variants and to explore the potential regulatory mechanism in schizophrenia (SCZ) …
variants and to explore the potential regulatory mechanism in schizophrenia (SCZ) …
[HTML][HTML] Association of schizophrenia polygenic risk score with data-driven cognitive subtypes: a six-year longitudinal study in patients, siblings and controls
TD Habtewold, EJ Liemburg, MA Islam… - Schizophrenia …, 2020 - Elsevier
Cross-sectional studies have shown that the polygenic risk score for schizophrenia (PRS
SCZ) may influence heterogeneity in cognitive performance although evidence from family …
SCZ) may influence heterogeneity in cognitive performance although evidence from family …