This study introduces an innovative detection system for multiple cancer biomarkers,
employing transcription isothermal amplification methods in conjunction with a tetrahedral …

We devised a novel strategy that relies on a combination of the primer exchange reaction
(PER) with transcription isothermal amplification, termed PER-Trap, for a sensitive …

Highly sensitive and stable acetylcholinesterase detection is critical for diagnosing and
treating various neurotransmission-related diseases. In this study, a novel colorimetric …

Cell-free protein synthesis (CFPS) reactions can be used to detect nucleic acids. However,
most CFPS systems rely on a toehold switch and exhibit the following critical limitations:(i) off …

The accurate and timely detection of disease biomarkers at the point-of-care is essential to
ensuring effective treatment and epidemiological surveillance. Here, we report the selection …

Biological macromolecules, such as DNA, RNA, and proteins in living organisms, form an
intricate network that plays a key role in many biological processes. Many attempts have …

The presence of the target causes the structural switch of a metastable hairpin template
probe (MH) for triggering a self-primed artificial biochemical circuit to produce numerous …

A novel CRISPR/Cas12a biosensor for specific detection of pathogenic bacteria was
constructed based on target nucleic acid (NA) inducing transcription-unleashed split crRNA …

DNA methyltransferase is significant in cellular activities and gene expression, and its
aberrant expression is closely linked to various cancers during initiation and progression …