The blood-brain barrier and the blood-cerebrospinal fluid barrier are major obstacles in
central nervous system (CNS) drug delivery, since they block most molecules from entering …

Intranasal (IN) delivery is a rapidly developing area for therapies with great potential for the
treatment of central nervous system (CNS) diseases. Moreover, in vivo imaging is becoming …

Background In nasal drug delivery system, nasal spray seems to be the most promising
delivery method for both local and systemic diseases therapy. Nasal deposition behavior is …

Aerosolized administration of biopharmaceuticals to the airways is a promising route for
nasal and pulmonary drug delivery, but− in contrast to small molecules− little is known about …

In this study, for the first time, we developed the novel combinatorial approach of poly-lactid-
co-glycolid acid (PLGA)-based nanoparticles (PLGA-NPs) containing rivastigmine (RV) and …

We have recently developed a region-specific catheter-based intranasal application method
in mice by using CT scan-based 3D cast models of the murine nose (DOI: 10.2376/0005 …

The immense increase of computational power in the past decades led to an evolution of
numerical simulations in all kind of engineering applications. New developments in medical …

Although intranasal delivery bypasses the blood-brain barrier (BBB), the anatomical location
of the olfactory mucosa and respiratory airflow interference lead to less brain-targeted drug …

The use of computational fluid dynamics (CFD) to model and predict surgical outcomes in
the nasal cavity is becoming increasingly popular. Despite a number of well-known nasal …

A mathematical approach was developed to estimate spray deposition patterns in the nasal
cavity based on the geometric relationships between the emitted spray plume and the …