Oral Molnupiravir and Nirmatrelvir/Ritonavir for the Treatment of COVID-19: A Literature Review with a Focus on Real-World Evidence

I Karniadakis, N Mazonakis, C Tsioutis… - Infectious Disease …, 2023 - mdpi.com
Vaccines remain the cornerstone of medical prevention and are highly effective in reducing
the risk of severe disease and death due to coronavirus disease 2019 (COVID-19). In the …

Nirmatrelvir/ritonavir for COVID-19: an overview of systematic reviews

M Cruciani, I Pati, F Masiello, S Pupella… - Journal of …, 2024 - academic.oup.com
Objectives A reappraisal of the validity of the conclusions of systematic reviews (SRs)
related to nirmatrelvir/ritonavir for the treatment of COVID-19. Methods An overview of SRs …

Comparison of baseline patient characteristics in Italian oncology drug monitoring registries and clinical trials: a real-world cross-sectional study

ML Iacovino, S Celant, L Tomassini… - The Lancet Regional …, 2024 - thelancet.com
Background Generalizability of registrative clinical trials to real-world clinical practice is
influenced by comparability of patients in the two settings. We compared characteristics of …

Evolution of in-hospital patient characteristics and predictors of death in the COVID-19 pandemic across four waves: are they moving targets with implications for …

EM Trecarichi, V Olivadese, C Davoli… - Frontiers in Public …, 2024 - frontiersin.org
Objectives The aim of this work was to study characteristics, outcomes and predictors of all-
cause death in inpatients with SARS-CoV-2 infection across the pandemic waves in one …

Nirmatrelvir/ritonavir and remdesivir against symptomatic treatment in high-risk COVID-19 outpatients to prevent hospitalization or death during the Omicron era: a …

S Rajme-López, BA Martinez-Guerra… - Therapeutic …, 2024 - journals.sagepub.com
Background: Even though worldwide death rates from coronavirus disease 2019 (COVID-
19) have decreased, the threat of disease progression and death for high-risk groups …

Shedding new light on COVID-19 therapeutics during the omicron era: a deeper dive into real-world data

A De Vito, A Colpani, G Madeddu - The Lancet Regional Health …, 2023 - thelancet.com
Ever since the emergence of the SARS-CoV-2 pandemic, the quest for efficacious
therapeutic interventions has become a focal point of international health research, focusing …