The vascular endothelium is composed of a monolayer of specialized cells (endothelial
cells), which form the interface between the underlying smooth muscle cells from the …

The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is
increasing worldwide. This triad of disorders is associated with considerable morbidity and …

Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory
system. Atherosclerosis is its major underlying cause. CVDs are chronic and can remain …

Aging is associated with a decline in physiological function and exercise performance.
These effects are mediated, at least in part, by an age-related decrease in the bioavailability …

The brain has impressive energy requirements and paradoxically, very limited energy
reserves, implying its huge dependency on continuous blood supply. Aditionally, cerebral …

Current research has described improving multisystem disease and organ function through
dietary nitrate (DN) supplementation. They have provided some evidence that these floras …

Chronic kidney disease (CKD) is a severe condition and a significant public health issue
worldwide, carrying the burden of an increased risk of cardiovascular events and mortality …

Exposure to microgravity results in vascular remodeling and cardiovascular dysfunction. To
elucidate the mechanism involved in this condition, we investigated whether endoplasmic …

Calcium/calmodulin-dependent protein kinases (CaMKs) are key regulators of calcium
signaling in health and disease. CaMKII is the most abundant isoform in the heart; although …

Heart failure with preserved ejection fraction (HFpEF) accounts for almost half of all heart
failure (HF) cases worldwide. Unfortunately, its incidence is expected to continue to rise, and …