Cannabis use and cannabis use disorder
Cannabis use disorder (CUD) is an underappreciated risk of using cannabis that affects~
10% of the 193 million cannabis users worldwide. The individual and public health burdens …
10% of the 193 million cannabis users worldwide. The individual and public health burdens …
[HTML][HTML] US epidemiology of cannabis use and associated problems
DS Hasin - Neuropsychopharmacology, 2018 - nature.com
This review provides an overview of the changing US epidemiology of cannabis use and
associated problems. Adults and adolescents increasingly view cannabis as harmless, and …
associated problems. Adults and adolescents increasingly view cannabis as harmless, and …
[HTML][HTML] A large-scale genome-wide association study meta-analysis of cannabis use disorder
Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …
(estimated twin and family heritability about 50–70%) and is associated with negative …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
RK Walters, R Polimanti, EC Johnson… - Nature …, 2018 - nature.com
Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …
polygenic architecture or its genetic relationship with other disorders. To discover loci …
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability
Cannabis use is a heritable trait that has been associated with adverse mental health
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …
[HTML][HTML] Lower-Risk Cannabis Use Guidelines (LRCUG) for reducing health harms from non-medical cannabis use: A comprehensive evidence and recommendations …
Background Cannabis use is common, especially among young people, and is associated
with risks for various health harms. Some jurisdictions have recently moved to …
with risks for various health harms. Some jurisdictions have recently moved to …
Genetics of substance use disorders in the era of big data
J Gelernter, R Polimanti - Nature Reviews Genetics, 2021 - nature.com
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
Cannabis and mental illness: a review
DJE Lowe, JD Sasiadek, AS Coles… - European archives of …, 2019 - Springer
With the increasing push to legalize cannabis in Western nations, there is a need to gage
the potential impact of this policy change on vulnerable populations, such as those with …
the potential impact of this policy change on vulnerable populations, such as those with …
Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study
BackgroundObservational associations between cannabis and schizophrenia are well
documented, but ascertaining causation is more challenging. We used Mendelian …
documented, but ascertaining causation is more challenging. We used Mendelian …