Obesity, manifested by increased adiposity, represents a main cause of morbidity in the
developed countries, causing increased risk of insulin resistance and type 2 diabetes …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in
regulating energy homeostasis and insulin sensitivity. WAT is characterised by its capacity to …

Mammalian adipose tissue is traditionally categorized into white and brown relating to their
function and morphology: while white serves as an energy storage, brown adipose tissue …

Over the last several years, the increasing prevalence of obesity has favored an intense
study of adipose tissue biology and the precise mechanisms involved in adipocyte …

Abstract Purpose of Review The global prevalence of type 2 diabetes (T2D) is escalating at
alarming rates, demanding the development of additional classes of therapeutics to further …

Obesity is the result of energy intake chronically exceeding energy expenditure. Classical
treatments against obesity do not provide a satisfactory long‐term outcome for the majority of …

The apelin receptor (APJ) is a member of the family A of G-protein-coupled receptors
(GPCRs) and is involved in range of physiological and pathological functions, including fluid …

Type 2 diabetes mellitus is one of the most prevalent metabolic diseases presenting with
systemic pathologies, including reproductive disorders in male diabetic patients. However …

Adipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and
beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT …