The global pandemic caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …

The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral
replication process, catalyzing the viral RNA synthesis using a metal ion-dependent …

Pyridinones have been adopted as an important block in medicinal chemistry that could
serve as hydrogen bond donors and acceptors. With the help of feasible synthesis routes via …

Quercetin, a potential polyphenolic which possesses several biological effects. The
influenza virus polymerase basic 2 (PB2) subunit of RNA polymerase responsible for …

Abstract The [1, 2, 4] triazolo [1, 5-a] pyrimidines (TPs) comprise an important class of non-
naturally occurring small molecules that aroused the interest of researches. This scaffold is …

Influenza PAN inhibitors are of particular importance in current efforts to develop a new
generation of antiviral drugs due to the growing emergence of highly pathogenic influenza …

Background: Coronavirus disease 2019 (COVID-19) has caused a global pandemic with a
high mortality and morbidity rate worldwide. The COVID-19 vaccines that are currently in …

Influenza A viruses possess a high antigenic shift, and the approved anti-influenza drugs are
extremely limited, which makes the development of novel anti-influenza drugs for the clinical …

WHO has declared COVID-19 a pandemic, which has affected the whole world and has
caused unprecedented social and economic disruption. Since the emergence of the …

During recent decades, a great variety of viral and host targets have been exploited for the
discovery of antiviral agents against human infectious diseases. 1 Although significant …