COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features
that predispose individuals to severe COVID-19, we developed a mechanistic, within-host …
that predispose individuals to severe COVID-19, we developed a mechanistic, within-host …
[HTML][HTML] Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19
J Neidleman, X Luo, AF George, M McGregor, J Yang… - Cell Reports, 2021 - cell.com
Although T cells are likely players in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2 …
(SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2 …
The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study
Objective To compare the levels of various cytokines between pregnant women with
confirmed coronavirus disease (COVID-19) infection and pregnant women without any …
confirmed coronavirus disease (COVID-19) infection and pregnant women without any …
Blood interferon-α levels and severity, outcomes, and inflammatory profiles in hospitalized COVID-19 patients
Background: Deficient interferon responses have been proposed as one of the relevant
mechanisms prompting severe manifestations of COVID-19. Objective: To evaluate the …
mechanisms prompting severe manifestations of COVID-19. Objective: To evaluate the …
Rationale for azithromycin in COVID-19: an overview of existing evidence
I Gyselinck, W Janssens… - BMJ Open …, 2021 - bmjopenrespres.bmj.com
Azithromycin has rapidly been adopted as a repurposed drug for the treatment of COVID-19,
despite the lack of high-quality evidence. In this review, we critically appraise the current …
despite the lack of high-quality evidence. In this review, we critically appraise the current …
Diverse immunological factors influencing pathogenesis in patients with COVID-19: a review on viral dissemination, immunotherapeutic options to counter cytokine …
AA Rabaan, SH Al-Ahmed, MA Garout, AM Al-Qaaneh… - Pathogens, 2021 - mdpi.com
The pathogenesis of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is still not fully unraveled. Though …
respiratory syndrome coronavirus 2 (SARS-CoV-2), is still not fully unraveled. Though …
Innate and adaptive immunity during SARS-CoV-2 infection: biomolecular cellular markers and mechanisms
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Complement anaphylatoxins and inflammatory cytokines as prognostic markers for COVID-19 severity and in-hospital mortality
B Alosaimi, A Mubarak, ME Hamed… - Frontiers in …, 2021 - frontiersin.org
COVID-19 severity due to innate immunity dysregulation accounts for prolonged
hospitalization, critical complications, and mortality. Severe SARS-CoV-2 infections involve …
hospitalization, critical complications, and mortality. Severe SARS-CoV-2 infections involve …
Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
Associations between Serum Interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐8, and IL‐10) and Disease Severity of COVID‐19: A Systematic Review and Meta‐Analysis
Y Chang, M Bai, Q You - BioMed Research International, 2022 - Wiley Online Library
Background. To investigate the association between interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐
8, and IL‐10) and the disease severity of coronavirus disease 2019 (COVID‐19). Materials …
8, and IL‐10) and the disease severity of coronavirus disease 2019 (COVID‐19). Materials …