Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease
A Alendar, A Berns - Genes & Development, 2021 - genesdev.cshlp.org
Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …
type of histone and DNA modifications governed by processes such as transcription, repair …
The interaction landscape between transcription factors and the nucleosome
Nucleosomes cover most of the genome and are thought to be displaced by transcription
factors in regions that direct gene expression. However, the modes of interaction between …
factors in regions that direct gene expression. However, the modes of interaction between …
Structural basis of nucleosome transcription mediated by Chd1 and FACT
L Farnung, M Ochmann, M Engeholm… - Nature Structural & …, 2021 - nature.com
Efficient transcription of RNA polymerase II (Pol II) through nucleosomes requires the help of
various factors. Here we show biochemically that Pol II transcription through a nucleosome …
various factors. Here we show biochemically that Pol II transcription through a nucleosome …
Nucleosome–Chd1 structure and implications for chromatin remodelling
Chromatin-remodelling factors change nucleosome positioning and facilitate DNA
transcription, replication, and repair. The conserved remodelling factor chromodomain …
transcription, replication, and repair. The conserved remodelling factor chromodomain …
Structure and regulation of the human INO80–nucleosome complex
R Ayala, O Willhoft, RJ Aramayo, M Wilkinson… - Nature, 2018 - nature.com
Access to DNA within nucleosomes is required for a variety of processes in cells including
transcription, replication and repair. Consequently, cells encode multiple systems that …
transcription, replication and repair. Consequently, cells encode multiple systems that …
Mechanism of DNA translocation underlying chromatin remodelling by Snf2
Chromatin remodellers include diverse enzymes with distinct biological functions, but
nucleosome-sliding activity appears to be a common theme,. Among the remodelling …
nucleosome-sliding activity appears to be a common theme,. Among the remodelling …
Bi-directional nucleosome sliding by the Chd1 chromatin remodeler integrates intrinsic sequence-dependent and ATP-dependent nucleosome positioning
Chromatin remodelers use a helicase-type ATPase motor to shift DNA around the histone
core. Although not directly reading out the DNA sequence, some chromatin remodelers …
core. Although not directly reading out the DNA sequence, some chromatin remodelers …
Structure of transcribing RNA polymerase II-nucleosome complex
Transcription of eukaryotic protein-coding genes requires passage of RNA polymerase II
(Pol II) through nucleosomes, but it is unclear how this is achieved. Here we report the cryo …
(Pol II) through nucleosomes, but it is unclear how this is achieved. Here we report the cryo …
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state
Chromatin remodelers are ATP-dependent enzymes that reorganize nucleosomes within all
eukaryotic genomes. Here we report a complex of the Chd1 remodeler bound to a …
eukaryotic genomes. Here we report a complex of the Chd1 remodeler bound to a …