Immune response and molecular mechanisms of cardiovascular adverse effects of spike proteins from SARS-CoV-2 and mRNA vaccines

P Bellavite, A Ferraresi, C Isidoro - Biomedicines, 2023 - mdpi.com
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus responsible for the
COVID-19 disease) uses the Spike proteins of its envelope for infecting target cells …

Blood-brain barrier function in response to SARS-CoV-2 and its spike protein

Ł Suprewicz, K Fiedoruk… - Neurologia i …, 2023 - journals.viamedica.pl
The typical manifestation of coronavirus 2 (CoV-2) infection is a severe acute respiratory
syndrome (SARS) accompanied by pneumonia (COVID-19). However, SARS-CoV-2 can …

SARS-CoV-2 structural proteins modulated blood-testis barrier-related proteins through autophagy in the primary sertoli cells

K Kang, YD Ma, SQ Liu, RW Huang, JJ Chen, LL An… - Viruses, 2023 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disrupts the blood-
testis barrier (BTB), resulting in alterations in spermatogenesis. However, whether BTB …

Towards Novel Biomimetic In Vitro Models of the Blood–Brain Barrier for Drug Permeability Evaluation

I Mármol, S Abizanda-Campo, JM Ayuso, I Ochoa… - Bioengineering, 2023 - mdpi.com
Current available animal and in vitro cell-based models for studying brain-related
pathologies and drug evaluation face several limitations since they are unable to reproduce …

Acute severe hypoglycemia alters mouse brain microvascular proteome

SSVP Sakamuri, VN Sure, L Oruganti… - Journal of Cerebral …, 2024 - journals.sagepub.com
Hypoglycemia increases the risk related to stroke and neurodegenerative diseases,
however, the underlying mechanisms are unclear. For the first time, we studied the effect of a …

Negative regulation of angiogenesis and the MAPK pathway may be a shared biological pathway between IS and epilepsy

L Fu, B Yu, B Lv, Y Tian, Y Zhang, H Chen, S Yang… - Plos one, 2023 - journals.plos.org
Ischemia stroke and epilepsy are two neurological diseases that have significant patient and
societal burden, with similar symptoms of neurological deficits. However, the underlying …

Protein profiling and assessment of amyloid beta levels in plasma in canine refractory epilepsy

S Phochantachinda, B Chantong… - Frontiers in Veterinary …, 2023 - frontiersin.org
Introduction The relationship between epilepsy and cognitive dysfunction has been
investigated in canines, and memory impairment was prevalent in dogs with epilepsy …

Gender-specific dysregulations of nondifferentially expressed biomarkers of metastatic colon cancer

M Duan, Y Liu, D Zhao, H Li, G Zhang, H Liu… - … Biology and Chemistry, 2023 - Elsevier
Colon cancer is a common cancer type in both sexes and its mortality rate increases at the
metastatic stage. Most studies exclude nondifferentially expressed genes from biomarker …

The S1 subunits of SARS-CoV-2 variants differentially trigger the IL-6 signaling pathway in human brain endothelial cells and downstream impact on microglia …

M Stangis, D Adesse, B Sharma, E Castro… - Neuroimmune …, 2024 - degruyter.com
Objectives Cerebrovascular complications are prevalent in COVID-19 infection and post-
COVID conditions; therefore, interactions of SARS-CoV-2 with cerebral microvascular cells …

[PDF][PDF] Inflammation Induction in the Neurovascular Unit by the S1 Subunit of SARS-CoV-2 Strains

MM Stangis - 2023 - scholarship.miami.edu
Neurological symptoms and complications are prevalent in COVID-19 infection; therefore,
interactions of SARS-CoV-2 with cerebral microvascular cells became an emerging concern …