A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology
Blood cells contain functionally important intracellular structures, such as granules, critical to
immunity and thrombosis. Quantitative variation in these structures has not been subjected …
immunity and thrombosis. Quantitative variation in these structures has not been subjected …
Association of inflammatory markers with cerebral small vessel disease in community-based population
L Jiang, X Cai, D Yao, J Jing, L Mei, Y Yang… - Journal of …, 2022 - Springer
Background This study investigated the relationships of neutrophil count (NC), neutrophil-to-
lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small …
lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small …
Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders
There is a long-standing interest in exploring the relationship between blood-based
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …
The genetics of human performance
Human physiology is likely to have been selected for endurance physical activity. However,
modern humans have become largely sedentary, with physical activity becoming a leisure …
modern humans have become largely sedentary, with physical activity becoming a leisure …
Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation
Genome-wide association studies (GWAS) have uncovered thousands of genetic variants
that influence risk for human diseases and traits. Yet understanding the mechanisms by …
that influence risk for human diseases and traits. Yet understanding the mechanisms by …
Molecular and cellular mechanisms that regulate human erythropoiesis
AL Caulier, VG Sankaran - Blood, The Journal of the American …, 2022 - ashpublications.org
To enable effective oxygen transport,∼ 200 billion red blood cells (RBCs) need to be
produced every day in the bone marrow through the fine-tuned process of erythropoiesis …
produced every day in the bone marrow through the fine-tuned process of erythropoiesis …
Variant to function mapping at single-cell resolution through network propagation
Genome-wide association studies in combination with single-cell genomic atlases can
provide insights into the mechanisms of disease-causal genetic variation. However …
provide insights into the mechanisms of disease-causal genetic variation. However …
Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair
Macrophage colony-stimulating factor (CSF1) is the primary growth factor required for the
control of monocyte and macrophage differentiation, survival, proliferation and renewal …
control of monocyte and macrophage differentiation, survival, proliferation and renewal …
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and
highlights a potential causal role in dementia Page 1 Chong et al. eLife 2022;11:e70382 …
highlights a potential causal role in dementia Page 1 Chong et al. eLife 2022;11:e70382 …
Cross-disorder genetic analysis of immune diseases reveals distinct gene associations that converge on common pathways
P Demela, N Pirastu, B Soskic - Nature Communications, 2023 - nature.com
Genome-wide association studies (GWAS) have mapped thousands of susceptibility loci
associated with immune-mediated diseases. To assess the extent of the genetic sharing …
associated with immune-mediated diseases. To assess the extent of the genetic sharing …