Background Hypertension, clinically defined by elevated blood pressure (BP), is an
important cause of mortality and morbidity worldwide. Many risk factors for hypertension are …

Objectives Though type 2 diabetes (T2D) has been known as a metabolic disease caused
by multiple factors, the etiology remains insufficiently understood. Here, we aimed to figure …

We assessed the causal relation of four glycemic traits and type 2 diabetes liability with 167
metabolites using Mendelian randomization with various sensitivity analyses and a reverse …

Previous genome-wide association studies revealed multiple common variants involved in
eczema but the role of rare variants remains to be elucidated. Here, we investigate the role …

Rationale: Age-related diseases like chronic obstructive pulmonary disease (COPD) occur
at higher rates in people living with human immunodeficiency virus (PLWH) than in …

Background Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-
wide association studies (GWAS) have identified genetic variants associated with SCZ and …

Background Previous studies have reported cross-sectional associations between
measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However …

We introduce mvSuSiE, a multi-trait fine-mapping method for identifying putative causal
variants from genetic association data (individual-level or summary data). mvSuSiE learns …

Kawasaki disease (KD) is an acute systemic vasculitis that occurs predominantly in children
under 5 years of age. Despite much study, the etiology of KD remains unknown. However …

Iron is essential for many biological processes, but iron levels must be tightly regulated to
avoid harmful effects of both iron deficiency and overload. Here, we perform genome-wide …