Integrins are heterodimeric transmembrane cell adhesion molecules made up of alpha (α)
and beta (β) subunits arranged in numerous dimeric pairings. These complexes have …

Adhesion to the extracellular matrix (ECM) is a crucial regulator of cell function, and it is now
well established that signaling by integrins mediates many of these effects. Ten years of …

Natural killer (NK) cells develop in the bone marrow, but their in vivo stages of maturation,
expansion and acquisition of receptors that guide target cell specificity are not well defined …

Multicellular organisms must coordinate signals from adhesion receptors with those from
other signalling receptors (for example, growth factor receptors). Here, we briefly review …

A detailed understanding of the biophysical features that affect cell growth and development
is important in guiding the design of biomimetic scaffolds. The cellular microenvironment is a …

The α4 integrins are indispensable for embryogenesis, haematopoiesis and immune
responses,, possibly because α4 regulates cellular functions differently from other integrins …

Metastasis, the major cause of cancer death, is a multistep process that requires interactions
between cancer cells and stromal cells and between cancer cells and extracellular matrix …

Mechanical tension is a critical determinant of cell growth, differentiation, apoptosis,
migration, and development. Integrins have been implicated in sensing force but little is …

Integrin receptors mediate adhesive events that are critical for a specific and effective
immune response to foreign pathogens. Integrin-dependent interactions of lymphocytes and …

In order to extravasate the bloodstream at specific sites of inflammation or antigen
presentation, circulating leukocytes must rapidly translate specific adhesive and stimulatory …