Liquid biopsies enable early detection and monitoring of diseases such as cancer, but their
sensitivity remains limited by the scarcity of analytes such as cell-free DNA (cfDNA) in blood …

Liquid biopsy provides a noninvasive window to the cancer genome and physiology. In
particular, cell-free DNA (cfDNA) is a versatile analyte for guiding treatment, monitoring …

Accurate discrimination between patients with and without cancer from cfDNA is crucial for
early cancer diagnosis. Herein, we develop and validate a deep-learning-based model …

Gastric cancer (GC) is one of the most prevalent malignant types worldwide, especially in
East Asia. Due to its frequently advanced stage at diagnosis, the mortality from GC is high …

Background Bloodstream infections remain a challenge for neonatologists, as traditional
culture-based methods are time-consuming and rely on adequate blood volume. Next …

Many studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in
the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore …

Background Many studies have demonstrated the high efficacy of cell-free nuclear DNA in
cancer diagnostics. Compared to nuclear DNA, mitochondrial DNA (mtDNA) exhibits distinct …

Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection.
However, the biological characteristics of ucfDNA are not well understood. We explored the …

Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue
damage and cellular stress. However, less is known about health behaviours, ageing …

As a member of the deoxyribonuclease 1 family, DNASE1L3 plays a significant role both
inside and outside the cell. However, the role of DNASE1L3 in hepatocellular carcinoma …