Activator protein-1 (AP-1) was first identified as a transcriptional factor that binds to an
essential cis-ele-ment of the human metallothionein lla (hMTIla) promoter [1]. AP-1 is …

A limited list of transcription factors are overactive in most human cancer cells, which makes
them targets for the development of anticancer drugs. That they are the most direct and …

An unusual pattern in a nucleic acid or protein sequence or a region of strong similarity
shared by two or more sequences may have biological significance. It is therefore desirable …

A 30-amino-acid segment of C/EBP, a newly discovered enhancer binding protein, shares
notable sequence similarity with a segment of the cellular Myc transforming protein. Display …

Binding of the human transcription factor Jun/AP-1 to a conserved 8 bp nucleotide sequence
(TRE) is responsible for increased transcription of different cellular genes in response to …

The serum response element (SRE) is a sequence required for transient transcriptional
activation of genes in response to growth factors. We have isolated cDNA clones encoding …

Cell lines stably transfected with metal inducible, MT-fos chimeric genes were used to study
the ability of the c-fos gene product, Fos, to act as a transcriptional trans-activator. In …

The c-jun and c-fos proto-oncogenes encode proteins that form a complex which regulates
transcription from promoters containing AP-1 activation elements. c&n has specific DNA …

Giucocorticoids are potent inhibitors of coiiagenase induction by phorbol esters and
inflammatory mediators. The target for this negatlve effect is the AP1 site within the …

The first fully repressible gene in fission yeast is described. In minimal medium it is highly
transcribed producing a mRNA which is 50-100 times more abundant than the cyc1 mRNA …