South Asians (from Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri
Lanka) make up one quarter of the world's population and are one of the fastest-growing …

The composition of the bile acid pool is a function of the microbial metabolism of bile acids in
the intestine. Perturbations of the microbiota shape the bile acid pool and modulate the …

The essential role of the brain in maintaining energy homeostasis has motivated the drive to
define the neural circuitry that integrates external and internal stimuli to enact appropriate …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

It is well-known that obesity is a complex multifactorial and heterogeneous condition with an
important genetic component. Recently, major advances in obesity research emerged …

Background Comorbidities are common in patients with heart failure (HF) and complicate
treatment and outcomes. We identified patterns of multimorbidity in Asian patients with HF …

The prevalence of diabetes is increasing globally, particularly in Asia. According to the 2013
Diabetes Atlas, an estimated 366 million people are affected by diabetes worldwide; 36% of …

Obesity is a growing epidemiological problem, as two-thirds of the adult population are
carrying excess weight. It is a risk factor for the development of cardiovascular diseases …

Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic
liver disease worldwide. Understanding the pathological and molecular hallmarks from its …

The metabolic syndrome is a cluster of risk factors (central obesity, hyperglycaemia,
dyslipidaemia and arterial hypertension), indicating an increased risk of diabetes …